MovDisordV3, France, Analysis, bibRecord, 000230

A Motor Cortex Excitability and Gait Analysis on Parkinsonian Patients

Identifieur interne : 000230 ( France/Analysis ); précédent : 000229; suivant : 000231

A Motor Cortex Excitability and Gait Analysis on Parkinsonian Patients

Auteurs : Prançois Vacherot [France] ; Shahram Attarian [France] ; Marianne Vaugoyeau [France] ; Jean-Philippe Azulay [France]

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:11-0065115

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Cortex moteur, Excitabilité, Homme, Stimulation magnétique transcrânienne.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Excitability, Human, Motor cortex, Nervous system diseases, Parkinson disease, Transcranial magnetic stimulation.

Abstract

Transcranial magnetic stimulation (TMS) parameters were recorded in a lower limb muscle and correlated with the gait parameters of 25 patients with Parkinson's disease (PD) with and without dopamine substitution treatment (DST) and 10 control subjects. Single and paired-pulse TMS were recorded in the tibialis anterior muscle (TA). Gait analysis was performed using a 3D motion analysis system. Parkinsonian patients (PP) did not differ from the control subjects (CS) in terms of relaxed motor threshold, active motor threshold (AMT), cortical silent period (CSP), motor-evoked potential (MEP) amplitude and area, or paired-pulse TMS with short interstimulus intervals (ISI). At longer ISIs, paired-pulse TMS showed that the amplitudes of the conditioned MEPs were lower in untreated PP than in CS. DST partially compensated for this difference. Gait analysis showed that the gait of PP undergoing no treatment was slower and the stride length shorter than normal. Both of these parameters improved under DST, however. Analysis of data obtained on all the subjects combined showed that both of the latter parameters were correlated with the paired-pulse MEP amplitude and area at longer ISIs. In PP, the cortical areas responsible for the lower limb movements seem to undergo intracortical facilitation (ICF) impairments, whereas the intracortical inhibition process is normal. The ICF level was found to be associated to the stride length and the velocity. The fact that only these two gait parameters were found to be dopa responsive indicates that dopaminergic treatment may improve gait disorders by restoring the ICF.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000780
to stream PascalFrancis, to step Curation: 002538
to stream PascalFrancis, to step Checkpoint: 000C37
to stream Main, to step Merge: 002824
to stream Main, to step Curation: 001F75
to stream Main, to step Exploration: 001F75
to stream France, to step Extraction: 000230

Links to Exploration step

Pascal:11-0065115

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">A Motor Cortex Excitability and Gait Analysis on Parkinsonian Patients</title>
<author><name sortKey="Vacherot, Prancois" sort="Vacherot, Prancois" uniqKey="Vacherot P" first="Prançois" last="Vacherot">Prançois Vacherot</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CNRS, UMR 6149, Pôle 3C, Equipe "Développement et Pathologie de l'Action" Université de Provence & CNRS, Centre Saint Charles</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Clinical Neuroscience, La Timone Hospital</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Attarian, Shahram" sort="Attarian, Shahram" uniqKey="Attarian S" first="Shahram" last="Attarian">Shahram Attarian</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Clinical Neuroscience, La Timone Hospital</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vaugoyeau, Marianne" sort="Vaugoyeau, Marianne" uniqKey="Vaugoyeau M" first="Marianne" last="Vaugoyeau">Marianne Vaugoyeau</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CNRS, UMR 6149, Pôle 3C, Equipe "Développement et Pathologie de l'Action" Université de Provence & CNRS, Centre Saint Charles</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CNRS, UMR 6149, Pôle 3C, Equipe "Développement et Pathologie de l'Action" Université de Provence & CNRS, Centre Saint Charles</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Clinical Neuroscience, La Timone Hospital</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">11-0065115</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 11-0065115 INIST</idno>
<idno type="RBID">Pascal:11-0065115</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000780</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002538</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000C37</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Vacherot P:a:motor:cortex</idno>
<idno type="wicri:Area/Main/Merge">002824</idno>
<idno type="wicri:Area/Main/Curation">001F75</idno>
<idno type="wicri:Area/Main/Exploration">001F75</idno>
<idno type="wicri:Area/France/Extraction">000230</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A Motor Cortex Excitability and Gait Analysis on Parkinsonian Patients</title>
<author><name sortKey="Vacherot, Prancois" sort="Vacherot, Prancois" uniqKey="Vacherot P" first="Prançois" last="Vacherot">Prançois Vacherot</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CNRS, UMR 6149, Pôle 3C, Equipe "Développement et Pathologie de l'Action" Université de Provence & CNRS, Centre Saint Charles</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Clinical Neuroscience, La Timone Hospital</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Attarian, Shahram" sort="Attarian, Shahram" uniqKey="Attarian S" first="Shahram" last="Attarian">Shahram Attarian</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Clinical Neuroscience, La Timone Hospital</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vaugoyeau, Marianne" sort="Vaugoyeau, Marianne" uniqKey="Vaugoyeau M" first="Marianne" last="Vaugoyeau">Marianne Vaugoyeau</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CNRS, UMR 6149, Pôle 3C, Equipe "Développement et Pathologie de l'Action" Université de Provence & CNRS, Centre Saint Charles</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CNRS, UMR 6149, Pôle 3C, Equipe "Développement et Pathologie de l'Action" Université de Provence & CNRS, Centre Saint Charles</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Clinical Neuroscience, La Timone Hospital</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Excitability</term>
<term>Human</term>
<term>Motor cortex</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Transcranial magnetic stimulation</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Cortex moteur</term>
<term>Excitabilité</term>
<term>Homme</term>
<term>Stimulation magnétique transcrânienne</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Transcranial magnetic stimulation (TMS) parameters were recorded in a lower limb muscle and correlated with the gait parameters of 25 patients with Parkinson's disease (PD) with and without dopamine substitution treatment (DST) and 10 control subjects. Single and paired-pulse TMS were recorded in the tibialis anterior muscle (TA). Gait analysis was performed using a 3D motion analysis system. Parkinsonian patients (PP) did not differ from the control subjects (CS) in terms of relaxed motor threshold, active motor threshold (AMT), cortical silent period (CSP), motor-evoked potential (MEP) amplitude and area, or paired-pulse TMS with short interstimulus intervals (ISI). At longer ISIs, paired-pulse TMS showed that the amplitudes of the conditioned MEPs were lower in untreated PP than in CS. DST partially compensated for this difference. Gait analysis showed that the gait of PP undergoing no treatment was slower and the stride length shorter than normal. Both of these parameters improved under DST, however. Analysis of data obtained on all the subjects combined showed that both of the latter parameters were correlated with the paired-pulse MEP amplitude and area at longer ISIs. In PP, the cortical areas responsible for the lower limb movements seem to undergo intracortical facilitation (ICF) impairments, whereas the intracortical inhibition process is normal. The ICF level was found to be associated to the stride length and the velocity. The fact that only these two gait parameters were found to be dopa responsive indicates that dopaminergic treatment may improve gait disorders by restoring the ICF.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<settlement><li>Marseille</li>
</settlement>
</list>
<tree><country name="France"><noRegion><name sortKey="Vacherot, Prancois" sort="Vacherot, Prancois" uniqKey="Vacherot P" first="Prançois" last="Vacherot">Prançois Vacherot</name>
</noRegion>
<name sortKey="Attarian, Shahram" sort="Attarian, Shahram" uniqKey="Attarian S" first="Shahram" last="Attarian">Shahram Attarian</name>
<name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name>
<name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name>
<name sortKey="Vacherot, Prancois" sort="Vacherot, Prancois" uniqKey="Vacherot P" first="Prançois" last="Vacherot">Prançois Vacherot</name>
<name sortKey="Vaugoyeau, Marianne" sort="Vaugoyeau, Marianne" uniqKey="Vaugoyeau M" first="Marianne" last="Vaugoyeau">Marianne Vaugoyeau</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000230 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000230 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Pascal:11-0065115
   |texte=   A Motor Cortex Excitability and Gait Analysis on Parkinsonian Patients
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

A Motor Cortex Excitability and Gait Analysis on Parkinsonian Patients

A Motor Cortex Excitability and Gait Analysis on Parkinsonian Patients

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri